
Credit: ABC7
Only now does the quiet intensity of Cleto Escobedo’s last chapter seem particularly evident. The disclosure of his medical information in recent days has created a picture that is remarkably similar to the accounts of many artists who persevere through illness while retaining the kind, uplifting demeanor that their fans love. According to his death certificate, cardiogenic shock was the direct cause of death. This is corroborated by a series of circumstances that indicate a particularly complicated medical history. According to those close to him, he handled it with poised strength, a quality he maintained throughout his professional life.
A more complete picture that combines personal devotion with professional resiliency is revealed by incorporating testimonies from coworkers, medical records, and longtime friends. As he spoke through obvious grief, Jimmy Kimmel referred to him as “the brother I got to choose,” providing a memory that felt remarkably resilient. He acknowledged that the tribute he tried to give during the November 11 taping was the most difficult he had ever tried. When he described how Cleto would send brief notes complimenting jokes, musical cues, or moments that might otherwise go unnoticed, his voice broke. These modest actions were incredibly successful in maintaining a relationship that lasted for decades.
| Full Name | Cleto Valentine Escobedo III |
|---|---|
| Born | August 23, 1966, Las Vegas, Nevada, USA |
| Died | November 11, 2025 (aged 59), Los Angeles, California |
| Illness | Several months of illness; complications after liver transplant; cardiogenic shock; vasodilatory shock; disseminated intravascular coagulation; alcoholic cirrhosis; sepsis; graft-versus-host disease; chronic kidney disease; pneumonia |
| Occupation | Musician, Bandleader, Saxophonist |
| Career Highlight | Leader of Cleto and the Cletones on Jimmy Kimmel Live! |
| Active Years | 1985–2025 |
| Family | Wife Lori, two children, parents Cleto Escobedo Jr. and Sylvia Escobedo |
| Reference | https://people.com |
Long before adulthood complicates it, their friendship started in Las Vegas, during the type of childhood that teaches you what loyalty feels like. They have maintained that youthful energy in a show that skillfully combined comedy and music since the beginning of their late-night collaboration. The presence of Cleto seemed so adaptable. He was the steady anchor on some nights. He was the spark that lifted a segment on other nights. He possessed the uncommon capacity to adapt quickly, which younger musicians frequently found especially useful when playing live.
Fans noticed that he was off stage for short periods of time during the pandemic. Although his absence caused a subtle ache for viewers who sensed something was wrong, the explanations were ambiguous. Information regarding his health has been circulating in whispers for the past year. There have been some reports of liver transplant complications. Others brought up immunosuppression’s vulnerability and protracted recovery. Stress, fatigue, or infection can greatly hinder recovery for musicians who have to deal with sleepless nights and rigorous schedules for decades.
Cleto’s dedication to music was particularly evident throughout his career. He toured with Paula Abdul, Marc Anthony, and Philip Bailey of Earth, Wind & Fire prior to joining Jimmy Kimmel. Even though those tours were known to be intense, he talked about them with a loving ease, as though the long nights were surprisingly emotionally affordable. The grind always seemed to bring him joy. From smoky jazz clubs to bright arenas to a late-night stage that millions of people frequented every night, his saxophone, whether tenor or alto, evolved into an extension of his storytelling.
He performed with his father, Cleto Escobedo Jr., on Jimmy Kimmel Live!. The picture of a father and son sharing a stage had its own emotional melody. It has evolved over the last ten years into a poignant reminder of how artistic ability is passed down through the generations like a family heirloom. Even those watching on screens were moved by the tenderness of his father’s performance the night his son died.
Fans’ and industry colleagues’ tributes emphasized the expanding relationship between creativity and mental health. Numerous people observed that Escobedo’s illness was indicative of a larger pattern: musicians dealing with the long-term consequences of continuous work. More artists have publicly discussed this in the last ten years, recognizing that good health frequently becomes the silent price of a successful career. Audiences were reminded of the humanity behind the spotlight by his passing, which brought this concern to light with startling clarity.
According to his coworkers, he simplified his energy-saving commitments while working while recovering. He continued to interact with the show’s musicians despite his growing weariness, providing feedback that was noticeably enhanced by his innate empathy. He had a strong belief in developing talent. Using his forty years of experience, he urged younger performers to follow their gut feelings, which proved to be a very successful strategy for boosting their self-esteem.
Cleto made the studio feel like a second home, as Jimmy Kimmel frequently remarked. He would warmly greet guests, joke with crew members, and tell brief tales about his kids or Las Vegas during rehearsals. These individual touches were especially creative in establishing the mood of a production that was renowned for its strict schedule and high standards. He was frequently the first person that early-stage performers were invited to appear on the show. He was a master at calming people down. The tension vanished with a few well-chosen words and a lighthearted smile.
According to industry insiders, his death might prompt big shows to reevaluate how they compensate their long-term creative employees. Networks could develop a system that is much quicker at identifying burnout symptoms by incorporating more robust wellness safeguards, particularly for musicians managing long-term illnesses. According to many insiders, that change might be prompted by Cleto’s experience.
Watching old Cleto videos is “comforting,” according to fans, especially now that every riff and every smile seems to be amplified. Kimmel claimed in the November 11 monologue that Cleto constantly emphasized to him how fortunate they were to collaborate. That sentiment is widely shared. It inspires viewers to cherish their relationships with a sense of urgency.
Conversations concerning community, care, and the silent bravery of artistic devotion may be sparked by Cleto’s story in the years to come. Although his illness was undoubtedly complicated, his legacy seems particularly evident. It endures in the songs he performed, the goodwill he showed, and the bonds he forged. His presence influenced late-night television for over twenty years, but his unwavering, warm, and rhythmic influence is still felt by those closest to him.

